Predef 2X


Why Buy Predef 2X Injection?


CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.


Each mL of PREDEF 2X Sterile Aqueous Suspension contains 2 mg of isoflupredone acetate; also 4.5 mg sodium citrate hydrous; 120 mg polyethylene glycol 3350; 1 mg povidone; 0.201 mg myristyl-gamma-picolinium chloride added as preservative. When necessary, pH was adjusted with hydrochloric acid and/or sodium hydroxide. It is for intramuscular or intrasynovial injection in animals and is indicated in situations requiring glucocorticoid, anti-inflammatory, and/or supportive effect.

Metabolic and Hormonal Effects

PREDEF 2X, a potent corticosteroid developed in the Research Laboratories of The Upjohn Company, has greater glucocorticoid activity than an equal quantity of prednisolone.

The glucocorticoid activity of PREDEF 2X is approximately 10 times that of prednisolone, 50 times that of hydrocortisone, and 67 times that of cortisone as measured by liver glycogen deposition in rats. The gluconeogenic activity is borne out by its hyperglycemic effect in both normal and ketotic cattle.

Key Benefits


For glucocorticoid, anti-inflammatory or supportive therapy in conditions such as overwhelming infections with sever toxicity, bovine ketosis, musculoskeletal conditions, allergic and acute hypersensitivity reactions, shock and supportive stress therapy for milk fever.

Key Features

  • Long-lasting: 48-hour gluconeogenic activity
  • Increases glucose levels quickly, with levels returning to normal within eight to 24 hours.
  • Intramuscular (IM) dose is 10 to 20 mg, repeated in 12 to 24 hours if needed.
  • The product to reach for when glucocorticoid therapy is indicated in the management of stress and bovine ketosis
  • The only corticosteroid approved by the U.S. Food and Drug Administration for use exclusively in large animals, including lactating cattle
  • No milk withholding required; seven-day pre-slaughter withdrawal

Dosing and Administration

Predef 2X is administered by deep intramuscular injection for systemic effect, or into joint cavity, tendon sheath or bursa for local effect. The usual intramuscular dose for cattle is 10 to 20 mg, according to the size of the animal and severity of the condition. The dose may be repeated in 12 to 24 hours if indicated.

As a result of its gluconeogenic and glycogen disposition activity, Predef 2X is an effective and valuable treatment for the endocrine and metabolic imbalance of primary bovine ketosis. Ketosis studies have demonstrated that relatively high initial doses of corticoids produce a more prompt recovery with a lower incidence of relapse than when relatively low doses are used, even when these are repeated. Response of ketosis to Predef 2X therapy parallels that derived with prednisolone. Predef 2X is 10 times more glucogenic than prednisolone. Thus, 10 mg of isoflupredone acetate therapeutically equals 100 mg of prednisolone.

In animals with overwhelmingly severe infections for which specific antibacterial therapy is available (e.g., critical pneumonia, peritonitis, endometritis, septic mastitis), Predef 2X therapy may be used as supportive therapy. Predef 2X therapy in the presence of infection should be administered in the shortest possible time compatible with maintenance of an adequate response, and antibacterial therapy should be continued for at least three days after the hormone has been withdrawn.

Predef 2X has been found useful as supportive therapy in the treatment of the stress associated with parturient paresis, i.e., milk fever. It should be given intramuscularly, before or after administration of the calcium infusion solutions commonly employed in treating the disease. Predef 2X is not to be added to the infusion solutions.


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